Standard Therapy for Localized Soft Tissue Sarcomas
نویسندگان
چکیده
منابع مشابه
Systemic Therapy for Advanced Soft Tissue Sarcomas
Soft tissue sarcomas (STS) are a rare, heterogeneous group of solid tumors in need of improved therapeutic options. First-line chemotherapy is considered the current standard of care for patients with advanced, symptomatic STS, but the median survival is only 8 to 12 months. Efforts to increase response rates by using combination or dose-dense regimens have largely failed to improve patient out...
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In this issue of The Lancet Oncology, Issels and colleagues1 describe a large, randomised phase 3 study assessing the effects of local hyperthermia in addition to chemotherapy and local therapy (surgery whenever possible with or without radiation) in a group of selected patients with intermediate or high-grade soft-tissue sarcomas greater than 5 cm, and deep.1 The trial was a multicentre study,...
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Stem cells are undifferentiated precursor cells with the capacity for proliferation or terminal differentiation. Progression down the differentiation cascade results in a loss of proliferative potential in exchange for the differentiated phenotype. This balance is tightly regulated in the physiologic state. Recent studies, however, have demonstrated that during tumorigenesis, disruptions preven...
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Soft tissue sarcomas are a heterogeneous group of malignant neoplasms of mesenchymal origin. They account for approximately 1% of all cancer diagnoses and 7% of pediatric malignancies (1,2). Just over half of these patients eventually succumb as a result of the disease. Soft tissue sarcomas typically present as asymptomatic large masses within the retroperitoneum or the proximal lower limbs but...
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This article discusses the epidemiology, diagnosis, and management of primary soft-tissue sarcomas (STS). These musculoskeletal tumors are a rare and heterogeneous group of malignancies, which are best managed by multidisciplinary teams in specialist sarcoma referral centers. Historically, the standard for local control of these tumors has been amputation. Evolutions in multimodality treatment ...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2017
ISSN: 0923-7534
DOI: 10.1093/annonc/mdx569